Comparative Genomics of the Eukaryotes

Abstract

A comparative analysis of the genomes of Drosophila melanogaster , Caenorhabditis elegans , and Saccharomyces cerevisiae —and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

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Affiliated Institutions

• University of California, Berkeley US
• Harvard University US
• Lawrence Berkeley National Laboratory US
• Frederick National Laboratory for Cancer Research US
• California Institute of Technology US
• National Cancer Institute US
• Wellcome Trust GB
• National Institute of Neurological Disorders and Stroke US
• University of Pennsylvania US
• Howard Hughes Medical Institute US
• Canada's Michael Smith Genome Sciences Centre CA
• Baylor Genetics US
• Harvard University Press US
• Baylor College of Medicine US
• National Institutes of Health US
• Massachusetts General Hospital US
• Centre National de la Recherche Scientifique FR
• European Bioinformatics Institute GB
• University of Maryland, Baltimore US
• Palo Alto University US
• Stanford University US
• Massachusetts Institute of Technology US
• University of California, San Diego US
• Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa ZA
• Columbia University US
• University of Leeds GB
• Centre de Génétique Moléculaire FR
• University of California, San Francisco US
• National Center for Biotechnology Information US

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