Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers

Abstract

Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers.

Keywords

Epidermal growth factor receptorKRASLung cancerLungCancer researchMedicineMutationEpidermal growth factorGene mutationExonTyrosine kinaseAdenocarcinomaPathologyInternal medicineOncologyBiologyCancerGeneReceptorColorectal cancerGenetics

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Publication Info

Year: 2005
Type: article
Volume: 97
Issue: 5
Pages: 339-346
Citations: 2367
Access: Closed

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APA Style

                            
                                
                                    Hisayuki Shigematsu, 
                                
                                    Lin Li, 
                                
                                    Tsuyoshi Takahashi
                                
                                et al.
                            
                            (2005). 
                            Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers. 
                            JNCI Journal of the National Cancer Institute
                            , 97
                            (5)
                            , 339-346.
                            https://doi.org/10.1093/jnci/dji055
                        

Identifiers

DOI: 10.1093/jnci/dji055