Abstract
Chromatin disruption and modification are associated with transcriptional regulation by diverse coactivators and corepressors. Here we discuss the possible structural basis and functional consequences of the observed alterations in chromatin associated with transcriptional activation and repression. Recent advances in defining the roles of individual histones and their domains in the assembly and maintenance of regulatory architectures provide a framework for understanding how chromatin remodelling machines, histone acetyltransferases and deacetylases function.
Keywords
ChromatinBiologyChIA-PETHistoneHistone-modifying enzymesTranscription coregulatorChromatin remodelingHistone AcetyltransferasesCell biologyGeneticsHistone codeComputational biologyNucleosomeDNA
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Publication Info
- Year
- 1999
- Type
- review
- Volume
- 27
- Issue
- 3
- Pages
- 711-720
- Citations
- 547
- Access
- Closed
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Cite This
A P Wolffe,
Jeffrey J. Hayes
(1999).
Chromatin disruption and modification.
Nucleic Acids Research
, 27
(3)
, 711-720.
https://doi.org/10.1093/nar/27.3.711
Identifiers
- DOI
- 10.1093/nar/27.3.711