Abstract
Acetylation of specific lysines of core histone N‐terminal tails correlates with chromatin assembly and specific regulation of gene expression. Core histones acetylated at particular lysines mediate effects on chromatin function; however, the manner in which different histone acetyltransferases (HATs) discriminate lysines is unknown. Here we propose a putative rule for lysine selection by HATs based on the primary sequence in the vicinity of lysines in the core histone N‐terminal tails and in flanking sequence. This provides insight into the molecular basis of site selection of core histones by HATs.
Keywords
Histone AcetyltransferasesAcetyltransferasesHistoneLysineChemistryBiochemistryAcetylationBromodomainComputational biologyBiologyAmino acidDNA
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Publication Info
- Year
- 1998
- Type
- article
- Volume
- 431
- Issue
- 2
- Pages
- 131-133
- Citations
- 25
- Access
- Closed
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Cite This
Akatsuki Kimura,
Masami Horikoshi
(1998).
How do histone acetyltransferases select lysine residues in core histones?.
FEBS Letters
, 431
(2)
, 131-133.
https://doi.org/10.1016/s0014-5793(98)00752-2
Identifiers
- DOI
- 10.1016/s0014-5793(98)00752-2