Ceritinib in <i>ALK</i> -Rearranged Non–Small-Cell Lung Cancer

2014 New England Journal of Medicine 1,444 citations

Abstract

Ceritinib was highly active in patients with advanced, ALK-rearranged NSCLC, including those who had had disease progression during crizotinib treatment, regardless of the presence of resistance mutations in ALK. (Funded by Novartis Pharmaceuticals and others; ClinicalTrials.gov number, NCT01283516.).

Keywords

CeritinibCrizotinibAnaplastic lymphoma kinaseMedicineALK inhibitorInternal medicineLung cancerOncologyGastroenterology

MeSH Terms

AdultAgedAged80 and overAnaplastic Lymphoma KinaseCarcinomaNon-Small-Cell LungDrug ResistanceNeoplasmFemaleHumansLung NeoplasmsMaleMaximum Tolerated DoseMiddle AgedProtein Kinase InhibitorsPyrimidinesReceptor Protein-Tyrosine KinasesRecombinationGeneticSulfonesTreatment OutcomeYoung Adult

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Publication Info

Year
2014
Type
article
Volume
370
Issue
13
Pages
1189-1197
Citations
1444
Access
Closed

Social Impact

Social media, news, blog, policy document mentions

Citation Metrics

1444
OpenAlex
17
Influential
1175
CrossRef

Cite This

Alice T. Shaw, Dong-Wan Kim, Ranee Mehra et al. (2014). Ceritinib in <i>ALK</i> -Rearranged Non–Small-Cell Lung Cancer. New England Journal of Medicine , 370 (13) , 1189-1197. https://doi.org/10.1056/nejmoa1311107

Identifiers

DOI
10.1056/nejmoa1311107
PMID
24670165
PMCID
PMC4079055

Data Quality

Data completeness: 86%