Abstract
The initial outgrowth of developing neuronal processes can be affected by a number of extrinsic interactions. Cell-cell interactions are also important in a later stage of neuronal outgrowth when processes grow into the region of their targets. The correct positioning of the process of a postembryonic sensory neuron, the touch cell AVM of the nematode Caenorhabditis elegans , at its synaptic targets requires the presence of a pair of embryonic interneurons, the BDU cells. These cells receive synapses from AVM but do not participate in the touch reflex circuit. Therefore, the AVM-BDU synapses may be required to stabilize the association between these cells and assist in the guidance of the AVM processes through a mature neuropil.
Keywords
NeuropilCaenorhabditis elegansNeuroscienceBiologyEmbryonic stem cellNeuronCellSensory systemProcess (computing)Central nervous systemComputer science
Affiliated Institutions
Related Publications
Combinatorial control of touch receptor neuron expression in <i>Caenorhabditis elegans</i>
ABSTRACT Six touch receptor neurons with distinctive morphological features sense gentle touch in Caenorhabditis elegans. Previous studies have identified three genes (lin-32, u...
mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans.
In the nematode Caenorhabditis elegans, microtubules with 15 protofilaments are a specialized feature of six touch-receptor neurons; microtubules found in other C. elegans neuro...
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
The heterchronic gene lin-14 controls the temporal sequence of developmental events in the Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that n...
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
BACKGROUND: The microRNAs (miRNAs) are an extensive class of small noncoding RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In Caenorhabdi...
Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus
Ultrastructural identification of mitotic neuronal precursors beneath the basal hippocampal granule cell layer was made using electron micrographs of [3H]thymidine-labeled cells...
Publication Info
- Year
- 1988
- Type
- article
- Volume
- 239
- Issue
- 4840
- Pages
- 643-645
- Citations
- 37
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
37
OpenAlex
Cite This
W. W. Walthall,
Martin Chalfie
(1988).
Cell-Cell Interactions in the Guidance of Late-Developing Neurons in <i>Caenorhabditis elegans</i>.
Science
, 239
(4840)
, 643-645.
https://doi.org/10.1126/science.3340848
Identifiers
- DOI
- 10.1126/science.3340848