Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2

Abstract

Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor–2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor–κB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.

Keywords

Innate immune systemToll-like receptorApoptosisCell biologyBiologyInflammationImmune systemActivator (genetics)TransfectionReceptorRespiratory burstImmunologyGeneBiochemistry

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Publication Info

Year: 1999
Type: article
Volume: 285
Issue: 5428
Pages: 736-739
Citations: 1468
Access: Closed

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APA Style

                            
                                
                                    Antonios O. Aliprantis, 
                                
                                    Ruey‐Bing Yang, 
                                
                                    Melanie R. Mark
                                
                                et al.
                            
                            (1999). 
                            Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2. 
                            Science
                            , 285
                            (5428)
                            , 736-739.
                            https://doi.org/10.1126/science.285.5428.736
                        

Identifiers

DOI: 10.1126/science.285.5428.736