CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

Keywords

Cancer-Associated FibroblastsStromal cellCancer researchBiologyCancer stem cellTumor microenvironmentCancerCancer cellLung cancerStem cellCell biologyPathologyMedicineTumor cells

Affiliated Institutions

Related Publications

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Xiaoqi Mao , Jin Xu , Wei Wang +7 more

Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor micr...

2021 Molecular Cancer 2011 citations

Diversity and Biology of Cancer-Associated Fibroblasts

Giulia Biffi , David A. Tuveson

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantial...

2020 Physiological Reviews 1103 citations

Tumor microenvironment complexity and therapeutic implications at a glance

Roghayyeh Baghban , Leila Roshangar , Rana Jahanban‐Esfahlan +6 more

The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is esse...

2020 Cell Communication and Signaling 1668 citations

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Tathiane M. Malta , Artem Sokolov , Andrew J. Gentles +97 more

Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for...

2018 Cell 2223 citations

Phenotype molding of stromal cells in the lung tumor microenvironment

Diether Lambrechts , Els Wauters , Bram Boeckx +15 more

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lun...

2018 Nature Medicine 1647 citations

Publication Info

Year: 2018
Type: article
Volume: 172
Issue: 4
Pages: 841-856.e16
Citations: 1191
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1191

OpenAlex

Cite This

APA Style

                            
                                
                                    Shicheng Su, 
                                
                                    Jianing Chen, 
                                
                                    Herui Yao
                                
                                et al.
                            
                            (2018). 
                            CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. 
                            Cell
                            , 172
                            (4)
                            , 841-856.e16.
                            https://doi.org/10.1016/j.cell.2018.01.009
                        

Identifiers

DOI: 10.1016/j.cell.2018.01.009