Abstract
MicroRNAs (miRNAs) form an extensive class of RNA molecules that regulate gene expression at post-transcriptional level. In recent years, much progress has been made in dissection of biogenesis and functions of miRNAs. There are at least several hundred miRNA genes in the human genome, and the emerging evidence suggests that miRNAs are broadly implicated in gene regulation. Here, we review some recent advances, and particularly we discuss how comparative genomics helps to identify novel miRNA genes, how studies in zebrafish reveal roles of miRNAs in morphogenesis, how changes in miRNA expression patterns are connected with cancer and how host-virus coevolution exploits miRNA regulatory pathways.
Keywords
BiologymicroRNAZebrafishGeneComputational biologyGeneticsRegulation of gene expressionDroshaGene expressionGenomicsGenomeRNA interferenceRNA
Affiliated Institutions
Related Publications
MicroRNA Biogenesis and Cancer
Abstract MicroRNAs (miRNA) are a recently discovered family of short non–protein-coding RNAs that negatively regulate gene expression. Recent studies of miRNAs highlight a requi...
Nuclear Export of MicroRNA Precursors
MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are processed from larger transcripts by sequential action of nuclear and cytoplasmic ribonucl...
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary...
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small RNAs from...
Identification of <i>cis</i>- and <i>trans</i>-regulatory variation modulating microRNA expression levels in human fibroblasts
MicroRNAs (miRNAs) are regulatory noncoding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Interindividual variati...
Publication Info
- Year
- 2005
- Type
- review
- Volume
- 14
- Issue
- suppl_2
- Pages
- R183-R190
- Citations
- 99
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
99
OpenAlex
Cite This
Eugène Berezikov,
Ronald H.A. Plasterk
(2005).
Camels and zebrafish, viruses and cancer: a microRNA update.
Human Molecular Genetics
, 14
(suppl_2)
, R183-R190.
https://doi.org/10.1093/hmg/ddi271
Identifiers
- DOI
- 10.1093/hmg/ddi271