Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease

Mark G. Olavesen; Jochen Hampe; Muddassar M. Mirza; Robert Saiz; Cathryn M. Lewis; Stephen Bridger; M. Dawn Teare; Douglas F. Easton; Thomas Herrmann; Gillian Scott; J. F. Hirst; Jeremy Sanderson; S V Hodgson; J. Lee; Andrew J. Macpherson; Stefan Schreiber; J E Lennard‐Jones; Mark Curran; Christopher G. Mathew

doi:10.1007/s002510050001

Keywords

BiologyInflammatory bowel diseaseSingle-nucleotide polymorphismGeneticsGeneHuman geneticsGenetic associationInterleukin 10DiseaseImmunologyInterleukinGenotypeInternal medicineCytokineMedicine

Affiliated Institutions

Related Publications

Cytokines in Inflammatory Disease

Shinwan Kany , Jan Tilmann Vollrath , Borna Relja

This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effec...

2019 International Journal of Molecular Sc... 1780 citations

Expression profiling of IL‐10‐regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL‐10 therapy

Mechthild Jung , Robert Sabat , Jörn Krätzschmar +9 more

Abstract Interleukin‐10 (IL‐10), originally identified as an inhibitor of pro‐inflammatory cytokine production, exerts multiple immunomodulatory functions. Its ability to inhibi...

2004 European Journal of Immunology 87 citations

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

Charles A. Dinarello

Abstract More than any other cytokine family, the IL-1 family of ligands and receptors is primarily associated with acute and chronic inflammation. The cytosolic segment of each...

2011 Blood 2126 citations

Targeting the NLRP3 inflammasome in inflammatory diseases

Matthew Mangan , Edward J. Olhava , William Roush +3 more

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- ...

2018 Nature Reviews Drug Discovery 1783 citations

Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells

Elisabeth Suri‐Payer , Harvey Cantor

Murine autoimmune gastritis, induced by neonatal thymectomy or the injection of CD25-depleted lymphocytes into nu/nu recipients, is characterized by an inflammatory infiltrate i...

2001 Journal of Autoimmunity 233 citations

Publication Info

Year: 2000
Type: article
Volume: 51
Issue: 1
Pages: 1-7
Citations: 38
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                
                                    Mark G. Olavesen, 
                                
                                    Jochen Hampe, 
                                
                                    Muddassar M. Mirza
                                
                                et al.
                            
                            (2000). 
                            Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease. 
                            Immunogenetics
                            , 51
                            (1)
                            , 1-7.
                            https://doi.org/10.1007/s002510050001
                        

Identifiers

DOI: 10.1007/s002510050001