An International Ki67 Reproducibility Study

Abstract

Substantial variability in Ki67 scoring was observed among some of the world's most experienced laboratories. Ki67 values and cutoffs for clinical decision-making cannot be transferred between laboratories without standardizing scoring methodology because analytical validity is limited.

Keywords

ReproducibilityConcordanceMedicineBreast cancerOncologyConsistency (knowledge bases)Medical physicsCancerPathologyInternal medicineStatisticsComputer scienceMathematics

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Publication Info

Year: 2013
Type: article
Volume: 105
Issue: 24
Pages: 1897-1906
Citations: 585
Access: Closed

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APA Style

                            
                                
                                    Mei‐Yin C. Polley, 
                                
                                    Samuel Leung, 
                                
                                    Lisa M. McShane
                                
                                et al.
                            
                            (2013). 
                            An International Ki67 Reproducibility Study. 
                            JNCI Journal of the National Cancer Institute
                            , 105
                            (24)
                            , 1897-1906.
                            https://doi.org/10.1093/jnci/djt306
                        

Identifiers

DOI: 10.1093/jnci/djt306