AlphaFold2 and its applications in the fields of biology and medicine

Keywords

BiologyComputational biologySystems biologyStructural biologyData scienceComputer scienceGenetics

Affiliated Institutions

Related Publications

Accurate prediction of protein structures and interactions using a three-track neural network

Minkyung Baek , Frank DiMaio , Ivan Anishchenko +29 more

Deep learning takes on protein folding In 1972, Anfinsen won a Nobel prize for demonstrating a connection between a protein’s amino acid sequence and its three-dimensional struc...

2021 Science 5139 citations

Evolutionary-scale prediction of atomic-level protein structure with a language model

Zeming Lin , Halil Akin , Roshan Rao +12 more

Recent advances in machine learning have leveraged evolutionary information in multiple sequence alignments to predict protein structure. We demonstrate direct inference of full...

2023 Science 3635 citations

pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination

Anna Lobley , Michael I. Sadowski , David T. Jones

Abstract Motivation: Generation of structural models and recognition of homologous relationships for unannotated protein sequences are fundamental problems in bioinformatics. Im...

2009 Bioinformatics 302 citations

Optimized Molecular Dynamics Force Fields Applied to the Helix−Coil Transition of Polypeptides

Robert B. Best , Gerhard Hummer

Obtaining the correct balance of secondary structure propensities is a central priority in protein force-field development. Given that current force fields differ significantly ...

2009 The Journal of Physical Chemistry B 879 citations

Highly accurate protein structure prediction with AlphaFold

John Jumper , K Taki , Alexander Pritzel +31 more

Abstract Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort ...

2021 Nature 39627 citations

Publication Info

Year: 2023
Type: review
Volume: 8
Issue: 1
Pages: 115-115
Citations: 426
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

AlphaFold2 and its applications in the fields of biology and medicine

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

426

OpenAlex

Cite This

APA Style

                            
                                
                                    Zhenyu Yang, 
                                
                                    Xiaoxi Zeng, 
                                
                                    Yi Zhao
                                
                                et al.
                            
                            (2023). 
                            AlphaFold2 and its applications in the fields of biology and medicine. 
                            Signal Transduction and Targeted Therapy
                            , 8
                            (1)
                            , 115-115.
                            https://doi.org/10.1038/s41392-023-01381-z
                        

Identifiers

DOI: 10.1038/s41392-023-01381-z