Abstract
Abstract Sequencing of the human, mouse, and rat genomes was accomplished more quickly than had seemed feasible a mere eight years ago. The accelerating pace of sequencing has been made possible by the development of large‐scale laboratory operations, assembly algorithms, and less so by changes in the underlying sequencing technologies. This short review summarizes the computational challenges of whole‐genome assembly and the algorithms and software systems that enabled the recent advances in sequencing of mammalian genomes.
Keywords
Sequence assemblyGenomeComputational biologyPaceHybrid genome assemblyDNA sequencingBiologyComputer scienceSoftwareHuman genomeGeneticsGeneGeography
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- 2005
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- other
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Serafim Batzoglou
(2005).
Algorithmic challenges in mammalian whole‐genome assembly.
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
.
https://doi.org/10.1002/047001153x.g401201
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- DOI
- 10.1002/047001153x.g401201