Abstract
We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.
Keywords
BiologyReceptor tyrosine kinaseProto-Oncogene Proteins c-kitMolecular biologyTyrosine kinaseHaematopoiesisComplementary DNATropomyosin receptor kinase CStem cellGeneStem cell factorPlatelet-derived growth factor receptorReceptorGenetics
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Publication Info
- Year
- 1991
- Type
- article
- Volume
- 88
- Issue
- 20
- Pages
- 9026-9030
- Citations
- 504
- Access
- Closed
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Cite This
William Matthews,
Craig T. Jordan,
Marc A. Gavin
et al.
(1991).
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit..
Proceedings of the National Academy of Sciences
, 88
(20)
, 9026-9030.
https://doi.org/10.1073/pnas.88.20.9026
Identifiers
- DOI
- 10.1073/pnas.88.20.9026