Abstract
Abstract Cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo 2 ) were measured in rats under nitrous oxide anaesthesia, using a 133 Xenon modification of the Kety and Schmidt inert gas technique with sampling of cerebral venous blood from the retroglenoid vein. Extracerebral contamination of the venous blood sampled was studied by comparing the rates at which the activity of 133 Xenon decreased in blood and tissues. Contamination was avoided by gentle compression of the contralateral retroglenoid vein during sampling. CBF and CMRo 2 of the rat brain were 80±2 and 7.6 ± 0.2 ml·(100 g) ‐1 , min ‐1 , respectively. These values are about 25% lower than those previously obtained for cerebral cortical tissue under similar conditions. Induced hypercapnia (Paco 2 about 70 mm Hg) or hypocapnia (Paco 2 15–20 mm Hg) gave rise to expected changes in CBF but did not alter CMRo 2 The CMRo 2 of the rat brain is at least twice that of the human brain. This species difference, which is similar to that previously reported for the oxygen uptake of cerebral tissue in vitro , probably reflects on inverse relationship between brain weight and neuronal packing density.
Keywords
HypocapniaCerebral blood flowHypercapniaBlood flowChemistryOxygenVenous bloodCerebral circulationAnesthesiaMedicineInternal medicineAcidosis
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Publication Info
- Year
- 1976
- Type
- article
- Volume
- 96
- Issue
- 1
- Pages
- 72-82
- Citations
- 102
- Access
- Closed
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Cite This
Bengt Nilsson,
B. K. Siesjö
(1976).
A Method for Determining Blood Flow and Oxygen Consumption in the Rat Brain.
Acta Physiologica Scandinavica
, 96
(1)
, 72-82.
https://doi.org/10.1111/j.1748-1716.1976.tb10172.x
Identifiers
- DOI
- 10.1111/j.1748-1716.1976.tb10172.x