Abstract

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron , a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

Keywords

Bacteroides thetaiotaomicronBiologyBacteroidesSymbiosisProteomeRepertoireGenomeMicrobiomeFunction (biology)MicrobiologyComputational biologyGeneticsWhole genome sequencingGeneBacteria

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Publication Info

Year
2003
Type
article
Volume
299
Issue
5615
Pages
2074-2076
Citations
1319
Access
Closed

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Cite This

Jian Xu, Magnus Bjursell, Jason Himrod et al. (2003). A Genomic View of the Human- <i>Bacteroides thetaiotaomicron</i> Symbiosis. Science , 299 (5615) , 2074-2076. https://doi.org/10.1126/science.1080029

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DOI
10.1126/science.1080029