Publications
17 shownThe Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
A translational medicine pipeline is described where human gut microbial communities and diets are re-created in gnotobiotic mice and the impact on microbe and host is defined u...
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
The normal range of physiological and metabolic phenotypes has been shaped by coevolution with microbial symbionts.
Predicting a Human Gut Microbiota’s Response to Diet in Gnotobiotic Mice
Model microbial communities in mouse guts respond quickly and predictably to dietary shifts.
Bacterial Community Variation in Human Body Habitats Across Space and Time
Growing on You The human gut and skin harbor diverse microbial communities that are known to vary strikingly among individuals. Here, Costello et al. (p. 1694 , published online...
Evolution of Mammals and Their Gut Microbes
Mammals are metagenomic in that they are composed of not only their own gene complements but also those of all of their associated microbes. To understand the coevolution of the...
Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins
We deeply sampled the organismal, genetic, and transcriptional diversity in fecal samples collected from a monozygotic (MZ) twin pair and compared the results to 1,095 communiti...
Evolution of Symbiotic Bacteria in the Distal Human Intestine
The adult human intestine contains trillions of bacteria, representing hundreds of species and thousands of subspecies. Little is known about the selective pressures that have s...
Direct sequencing of the human microbiome readily reveals community differences
Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity ca...
Ribosomal RNA diversity predicts genome diversity in gut bacteria and their relatives
The mammalian gut is an attractive model for exploring the general question of how habitat impacts the evolution of gene content. Therefore, we have characterized the relationsh...
The gut microbiota as an environmental factor that regulates fat storage
New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (mi...
Obesity alters gut microbial ecology
We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob / ob mice, lean ob /+ and wild-type siblings, and ...
Metagenomic Analysis of the Human Distal Gut Microbiome
The human intestinal microbiota is composed of 10 13 to 10 14 microorganisms whose collective genome (“microbiome”) contains at least 100 times as many genes as our own genome. ...
Frequent Co-Authors
Researcher Info
- h-index
- 17
- Publications
- 17
- Citations
- 88,307
- Institution
- Washington University in St. Louis
External Links
Identifiers
- ORCID
- 0000-0001-8304-3548
Impact Metrics
h-index: Number of publications with at least h citations each.