A Droplet‐Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor‐Diffusion...

Abstract

On-chip protein crystallization and diffraction: Proteins can be crystallized in nanoliter volumes by using both microbatch and vapor-diffusion techniques inside composite PDMS/glass microfluidic devices (PDMS=polydimethylsiloxane). The quality of crystals can be assessed directly by on-chip X-ray diffraction.

Keywords

PolydimethylsiloxaneCrystallizationDiffractionMicrofluidicsMaterials scienceComposite numberDiffusionMicrofluidic chipProtein crystallizationX-ray crystallographyChipCapillary actionNanotechnologyChemical engineeringOpticsComposite materialComputer sciencePhysicsEngineeringThermodynamicsTelecommunications

Affiliated Institutions

University of Chicago US

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Publication Info

Year: 2004
Type: article
Volume: 43
Issue: 19
Pages: 2508-2511
Citations: 385
Access: Closed

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Cite This

APA Style

                            
                                
                                    Bo Zheng, 
                                
                                    Joshua D. Tice, 
                                
                                    L. Spencer Roach
                                
                                et al.
                            
                            (2004). 
                            A Droplet‐Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor‐Diffusion Methods with On‐Chip X‐Ray Diffraction. 
                            Angewandte Chemie International Edition
                            , 43
                            (19)
                            , 2508-2511.
                            https://doi.org/10.1002/anie.200453974
                        

Identifiers

DOI: 10.1002/anie.200453974