A census of amplified and overexpressed human cancer genes

Thomas Santarius; Janet Shipley; Daniel Brewer; Michael R. Stratton; Colin S. Cooper

doi:10.1038/nrc2771

Abstract

Integrated genome-wide screens of DNA copy number and gene expression in human cancers have accelerated the rate of discovery of amplified and overexpressed genes. However, the biological importance of most of the genes identified in such studies remains unclear. In this Analysis, we propose a weight-of-evidence based classification system for identifying individual genes in amplified regions that are selected for during tumour development. In a census of the published literature we have identified 77 genes for which there is good evidence of involvement in the development of human cancer.

Keywords

GeneHuman genomeBiologyGeneticsCancerGenomeComputational biologyDNA

MeSH Terms

AnimalsGene AmplificationGene DosageGene Expression ProfilingGene Expression RegulationNeoplasticGenomeHumanHumansMolecular Sequence DataNeoplasms

Affiliated Institutions

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Publication Info

Year: 2009
Type: review
Volume: 10
Issue: 1
Pages: 59-64
Citations: 559
Access: Closed

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APA Style

                            
                                
                                    Thomas Santarius, 
                                
                                    Janet Shipley, 
                                
                                    Daniel Brewer
                                
                                et al.
                            
                            (2009). 
                            A census of amplified and overexpressed human cancer genes. 
                            Nature reviews. Cancer
                            , 10
                            (1)
                            , 59-64.
                            https://doi.org/10.1038/nrc2771
                        

Identifiers

DOI: 10.1038/nrc2771
PMID: 20029424

Data Quality

Data completeness: 86%