A Catalog of Reference Genomes from the Human Microbiome

William Nelson , George M. Weinstock , Sarah K. Highlander , William Nelson , George M. Weinstock , Sarah K. Highlander , Kim C. Worley , Heather H. Creasy , Jennifer R. Wortman , Douglas B. Rusch , Makedonka Mitreva , Erica Sodergren , Asif Chinwalla , Michael Feldgarden , Dirk Gevers , Brian J. Haas , Ramana Madupu , Doyle V. Ward , Bruce W. Birren , Richard A. Gibbs , Barbara A. Methé , Joseph F. Petrosino , Robert L. Strausberg , Granger Sutton , Owen White , Richard K. Wilson , Scott Durkin , Michelle Giglio , Sharvari Gujja , Clint Howarth , Chinnappa D. Kodira , Nikos C. Kyrpides , Teena Mehta , Donna M. Muzny , M.A. Pearson , Kymberlie Pepin , Amrita Pati , Xiang Qin , Chandri Yandava , Qiandong Zeng , Lan Zhang , Aaron M. Berlin , Lei Chen , Theresa A. Hepburn , Justin Johnson , Jamison McCorrison , Jason Miller , Pat Minx , Chad Nusbaum , Carsten Russ , Sean M. Sykes , Chad Tomlinson , Sarah Young , Wesley C. Warren , Jonathan H. Badger , Jonathan Crabtree , Victor Markowitz , Joshua Orvis , Andrew Cree , Steve Ferriera , Lucinda Fulton , Robert S. Fulton , Marcus Gillis , Lisa Hemphill , Vandita Joshi , Christie Kovar , Manolito Torralba , Kris A. Wetterstrand , Amr Abouellleil , Aye Wollam , Christian Buhay , Yan Ding , Shannon Dugan , Michael G. FitzGerald , Mike Holder , Jessica B. Hostetler , Sandra W. Clifton , Emma Allen‐Vercoe , Ashlee M. Earl , Candace N. Farmer , Konstantinos Liolios , Michael G. Surette , Qiang Xu , Craig Pohl , Katarzyna Wilczek-Boney , Dianhui Zhu
2010 Science 703 citations

Abstract

News from the Inner Tube of Life A major initiative by the U.S. National Institutes of Health to sequence 900 genomes of microorganisms that live on the surfaces and orifices of the human body has established standardized protocols and methods for such large-scale reference sequencing. By combining previously accumulated data with new data, Nelson et al. (p. 994 ) present an initial analysis of 178 bacterial genomes. The sampling so far barely scratches the surface of the microbial diversity found on humans, but the work provides an important baseline for future analyses.

Keywords

MicrobiomeComputational biologyGenomeHuman genomeHuman microbiomeBiologyEvolutionary biologyData scienceGeneticsComputer scienceGene

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Publication Info

Year
2010
Type
article
Volume
328
Issue
5981
Pages
994-999
Citations
703
Access
Closed

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William Nelson, George M. Weinstock, Sarah K. Highlander et al. (2010). A Catalog of Reference Genomes from the Human Microbiome. Science , 328 (5981) , 994-999. https://doi.org/10.1126/science.1183605

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DOI
10.1126/science.1183605