Vertex Pharmaceuticals (United States) - Academic Profile

Publications

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A global reference for human genetic variation

Adam Auton , Gonçalo R. Abecasis , David Altshuler +97 more

2015 Nature 18713 citations

AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules

David A. Pearlman , David A. Case , James W. Caldwell +6 more

1995 Computer Physics Communications 3086 citations

Consensus Scoring: A Method for Obtaining Improved Hit Rates from Docking Databases of Three-Dimensional Structures into Proteins

Paul S. Charifson , Joseph J. Corkery , Mark A. Murcko +1 more

We present the results of an extensive computational study in which we show that combining scoring functions in an intersection-based consensus approach results in an enhancemen...

1999 Journal of Medicinal Chemistry 682 citations

A detailed comparison of current docking and scoring methods on systems of pharmaceutical relevance

Emanuele Perola , W. Patrick Walters , Paul S. Charifson

Abstract A thorough evaluation of some of the most advanced docking and scoring methods currently available is described, and guidelines for the choice of an appropriate protoco...

2004 Proteins Structure Function and Bioin... 445 citations

Affiliated Researchers

Institution Info

Type: company
Country: US
Publications: 4
Citations: 22,926

External Links

Identifiers

ROR: https://ror.org/00anb1726