Shenyang Pharmaceutical University

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types

Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and t...

Exploring structure influence of mPEG-PLGA nanocarriers on their interaction with physiopathological barriers in the lung and anti-lung cancer effect

Combination Therapy with Azithromycin and Clostridium butyricum Retains Anti-Diarrheal Efficacy but Partially Compromises Gut Microbiota Restoration Compared to Probiotics Monotherapy

Most probiotics require separate administration from antibiotics due to sensitivity issues. Clostridium butyricum, however, exhibits intrinsic resistance, making it a promising ...

Discovery of a Novel Target Inhibitor Theaflavin against UDP-Glucose Pyrophosphorylase 2 and Its Role in Attenuating the Malignant Phenotype of Liver Cancer Cells via Perturbation of Glucose Metabolism

UDP-glucose pyrophosphorylase 2 (UGP2), the unique mammalian enzyme converting glucose-1-phosphate to UDP-glucose, is upregulated in hepatocellular carcinoma (HCC) and other mal...

The role of ADAM8 in intrahepatic cholangiocarcinoma

Oxidized- and hydroxylated-pennogenin saponins from the rhizomes of Paris fargesii and their hemostatic activity

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Abstract Type 2 diabetes mellitus (T2DM) persists as a global health challenge, with current therapies inadequately addressing the intertwined pathologies of hyperglycemia, oxid...

Scopolamine exerted antidepressant-like behavioral effects via restoring the synaptic plasticity in CRS-treated mice