How mitochondria produce reactive oxygen species
The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde re...
Publications
View AllItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that ...
Affiliated Researchers
Institution Info
- Type
- facility
- Country
- GB
- Publications
- 2
- Citations
- 9,392
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- ROR
- https://ror.org/01vdt8f48