MRC Laboratory for Molecular Cell Biology

Programmed Cell Death in Animal Development

Cell cycle control in cancer

Virus Entry: Open Sesame

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

Members of the Rho family of small guanosine triphosphatases (GTPases) regulate the organization of the actin cytoskeleton; Rho controls the assembly of actin stress fibers and ...

Content-aware image restoration: pushing the limits of fluorescence microscopy

TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines

TrackMate is an automated tracking software used to analyze bioimages and is distributed as a Fiji plugin. Here, we introduce a new version of TrackMate. TrackMate 7 is built to...

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

Programmed cell death and Bcl-2 protection in very low oxygen

Programmed cell death (PCD) is a fundamental feature of animal cells, but the mechanism remains unknown. Similarly, the Bcl-2 oncoprotein can suppress PCD in a variety of cell t...

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

Interaction of cells with extracellular matrix via integrin adhesion receptors plays an important role in a wide range of cellular: functions, for example cell growth, movement,...