Dartmouth Psychiatric Research Center

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation hav...

To be or not to be active: the stochastic nature of enhancer action

Transcriptional enhancers are traditionally considered to regulate the rate at which a linked promoter transcribes mRNA, but recent experiments suggest a reevaluation of this mo...

A Three-Component Model for Reengineering Systems for the Treatment of Depression in Primary Care

To be or not to be active: the stochastic nature of enhancer action

Transcriptional enhancers are traditionally considered to regulate the rate at which a linked promoter transcribes mRNA, but recent experiments suggest a reevaluation of this mo...