Werner Risau

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

The endothelial cell-specific vascular endothelial growth factor (VEGF) and its cellular receptors Flt-1 and Flk-1 have been implicated in the formation of the embryonic vascula...

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

Abstract Embryonic stem cells (ESC) have been established previously from the inner cell mass cells of mouse blastocysts. In suspension culture, they spontaneously differentiate...

Differentiation of endothelium

Vascular endothelial cells cover the entire inner surface of blood vessels in the body. They play an important role in tissue homeostasis, fibrinolysis and coagulation, blood‐ti...

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

ABSTRACT We are interested in the molecular mechanisms that are involved in the development of the vascular system. In order to respond to morphogenetic and mitogenic signals, e...