Stephen P. Jackson

The DNA-damage response in human biology and disease

DNA double-strand breaks: signaling, repair and the cancer connection

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Left unrepaired, the myriad types of damage that can occur in genomic DNA pose a serious threat to the faithful transmission of the correct complement of genetic material. Defec...

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

The DNA-dependent protein kinase is a mammalian protein complex composed of Ku70, Ku80, and DNA-PKcs subunits that has been implicated in DNA double-strand break repair and V(D)...