Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and...
<p>Expression of high FG motif valence NHA9 constructs in lin<sup>−</sup> HSPCs leads to hematopoietic cell transformation and aberrant expression of <i>...
<p>DNA binding by the HOXA9 homeodomain of NHA9 influences puncta morphology and behavior. <b>A,</b> Representative confocal microscopy image of live HEK293T c...
<p>Mutation of multiple F and FG residues in the FG-rich IDR of NHA9 alters puncta formation in cells. <b>A,</b> Schematic of NHA9 and mutant constructs used i...
<p>Mutation of F and FG residues in the FG-rich IDR of NHA9 alters LLPS behavior <i>in vitro</i>. <b>A–C,</b> Confocal fluorescence micrographs of ...
<p>Additional leukemia-associated NUP98 FOs form nuclear puncta and transform lin<sup>−</sup> HSPCs. <b>A,</b> Schematic of NHA9 and three addition...
<p>The NHA9 constructs form puncta in lin<sup>−</sup> HSPCs. <b>A–G,</b> Representative images of live lin<sup>−</sup> HSPCs expressing...
h-index: Number of publications with at least h citations each.