Supplementary Figure S6 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
<p>Loss of GRAMD1B promotes tumor cell invasion in human melanoma cells</p>
<p>Loss of GRAMD1B promotes tumor cell invasion in human melanoma cells</p>
<p>Supp. Fig. S5 shows that GRAMD1B is a metastasis suppressor in human melanoma</p>
<p>Supplementary Table S1. List of genes predictive of metastasis from AVAST-M trial. </p>
<p>Supp Table S7: GSEA Analysis</p>
<p>Cholesterol overload activates AP-1 via ERK signaling to mediate invasion upon GRAMD1B loss in melanoma.</p>
<p>Supplementary Table S2. David GO analysis of AVAST-M signature</p>
<p>Loss of GRAMD1B suppresses de novo cholesterol synthesis in melanoma cells.</p>
<p>CRISPR Sequencing of MAS2X tumors.</p>
<p>Supplementary Table S5. Normalized Counts of transcripts in GRAMD1B KO and NT cells.</p>
<p>Supp Table S4 has a list of antibodies and other resources</p>
<p>Validation of gramd1b depletion in zebrafish cells and tumors.</p>
<p>The AVAST-M trial identifies a signature predictive of metastatic relapse</p>
<p>Supp Table S3 has a List of Oligonucleotides Sequences</p>
<p>An in vivo screen identifies metastasis suppressors in melanoma.</p>
<p>Supp Table S6 Differentially Expressed Genes</p>
h-index: Number of publications with at least h citations each.