High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers
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Publications
7 shownMutational Analysis of the Tyrosine Kinome in Colorectal Cancers
Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][...
Incidence and functional consequences of <i>hMLH1</i> promoter hypermethylation in colorectal carcinoma
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG...
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alte...
The Genomic Landscapes of Human Breast and Colorectal Cancers
Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA ...
Somatic mutations in the chromatin remodeling gene <i>ARID1A</i> occur in several tumor types
Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutation...
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
Mutations of the p53 gene occur commonly in colorectal carcinomas and the wild-type p53 allele is often concomitantly deleted. These findings suggest that the wild-type gene may...
Frequent Co-Authors
Researcher Info
- h-index
- 7
- Publications
- 7
- Citations
- 13,753
- Institution
- Case Western Reserve University
External Links
Identifiers
- ORCID
- 0000-0001-5369-5254
Impact Metrics
h-index
7
h-index: Number of publications with at least h citations each.