Robert T. Abraham

Cell cycle checkpoint signaling through the ATM and ATR kinases

The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular me...

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

The immunosuppressant rapamycin interferes with G 1 -phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). m...

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxicstress is only par...