The large subunit of replication factor C is a substrate for caspase-3 invitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis
Caspase-3 is an ICE-like protease activated during apoptosis induced by different stimuli. Poly(ADP-ribose) polymerase (PARP), the first characterized substrate of caspase-3, sh...