Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
Protein phosphorylation during the cell cycle may be an all-or-none process in many instances.
Publications
8 shownFigure 3 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>SMYD3–RNF113A methylation signaling in SCLC cell lines. <b>A,</b> Immunodetection of endogenous RNF113A K20me3 following immunoprecipitation of total RNF113...
Figure 1 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>SMYD3 is a candidate regulator of SCLC susceptibility to alkylating chemotherapy. <b>A,</b> Synthetic lethality screening using a library composed of 285 ch...
Figure 4 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>RNF113A is a phosphoprotein and its methylation repels the phosphatase PP4. <b>A,</b> SILAC quantitative proteomics analysis of proteins that interact with ...
Figure 2 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>Identification of RNF113A as a novel methylated substrate of SMYD3. <b>A,</b> Recombinant SMYD3 was used for <i>in vitro</i> methylation reactio...
Figure 5 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>Methylation–phosphorylation cross-talk regulation of RNF113A affects its E3 ligase activity. <b>A,</b> Immunodetection of autoubiquitinated RNF113A after TU...
Figure 7 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>SMYD3 inhibition sensitizes SCLC to alkylating agents <i>in vivo</i>. <b>A,</b> Schematic of an SCLC mouse model with conditional deletion of &l...
Figure 6 from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
<p>RNF113A regulation affects its function in DNA dealkylation repair. <b>A,</b> Representative images of MMS-induced ASCC3 foci in sh<i>SMYD3</i> ...
Frequent Co-Authors
Researcher Info
- h-index
- 1
- Publications
- 8
- Citations
- 1,493
- Institution
- Max Planck Institute of Biochemistry
External Links
Identifiers
- ORCID
- 0000-0003-0836-6894
Impact Metrics
h-index
1
h-index: Number of publications with at least h citations each.