Michael J. Tocci

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as ...

Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

Interleukin 1 (IL-1) is a lymphokine secreted by monocytes in response to a variety of inflammatory stimuli. IL-1 beta, the predominant form of IL-1 produced by human monocytes,...