Lin Tian

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of...

Multiple dynamic representations in the motor cortex during sensorimotor learning

A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging<i>In Vivo</i>

Fluorescent calcium indicator proteins, such as GCaMP3, allow imaging of activity in genetically defined neuronal populations. GCaMP3 can be expressed using various gene deliver...

Activity in motor–sensory projections reveals distributed coding in somatosensation

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design

The genetically encoded calcium indicator GCaMP2 shows promise for neural network activity imaging, but is currently limited by low signal-to-noise ratio. We describe x-ray crys...