A connectome and analysis of the adult Drosophila central brain
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly ...
Publications
8 shownA Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping....
Figure 6 from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
<p>Expression of high FG motif valence NHA9 constructs in lin<sup>−</sup> HSPCs leads to hematopoietic cell transformation and aberrant expression of <i>...
Figure 2 from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
<p>DNA binding by the HOXA9 homeodomain of NHA9 influences puncta morphology and behavior. <b>A,</b> Representative confocal microscopy image of live HEK293T c...
Figure 3 from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
<p>Mutation of multiple F and FG residues in the FG-rich IDR of NHA9 alters puncta formation in cells. <b>A,</b> Schematic of NHA9 and mutant constructs used i...
Figure 4 from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
<p>Mutation of F and FG residues in the FG-rich IDR of NHA9 alters LLPS behavior <i>in vitro</i>. <b>A–C,</b> Confocal fluorescence micrographs of ...
Figure 7 from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
<p>Additional leukemia-associated NUP98 FOs form nuclear puncta and transform lin<sup>−</sup> HSPCs. <b>A,</b> Schematic of NHA9 and three addition...
Figure 5 from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
<p>The NHA9 constructs form puncta in lin<sup>−</sup> HSPCs. <b>A–G,</b> Representative images of live lin<sup>−</sup> HSPCs expressing...
Frequent Co-Authors
Researcher Info
- h-index
- 2
- Publications
- 8
- Citations
- 2,238
- Institution
- Howard Hughes Medical Institute
External Links
Identifiers
- ORCID
- 0000-0002-9274-5928
Impact Metrics
h-index
2
h-index: Number of publications with at least h citations each.