Joshua C. Denny

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations

Abstract Motivation: Emergence of genetic data coupled to longitudinal electronic medical records (EMRs) offers the possibility of phenome-wide association scans (PheWAS) for di...

The “All of Us” Research Program

Knowledge gained from observational cohort studies has dramatically advanced the prevention and treatment of diseases. Many of these cohorts, however, are small, lack diversity,...

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls. Both of the widely used...