Induction of Homologous Recombination in Mammalian Chromosomes by Using the I-<i>Sce</i>I System of <i>Saccharomyces cerevisiae</i>
The mitochondrial intron-encoded endonuclease I-SceI of Saccharomyces cerevisiae has an 18-bp recognition sequence and, therefore, has a very low probability of cutting DNA, eve...