Institut Pasteur

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

The formation of skeletal muscle: from somite to limb

Abstract During embryogenesis, skeletal muscle forms in the vertebrate limb from progenitor cells originating in the somites. These cells delaminate from the hypaxial edge of th...

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

Significance The pandemic potential of coronaviruses was recently demonstrated twice by global outbreaks of deadly pneumonia. The spike (S) glycoprotein initiates infection thro...

Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy

The human gene damage index as a gene-level approach to prioritizing exome variants

Significance The protein-coding exome of a patient with a monogenic disease contains about 20,000 variations, of which only one or two are disease causing. When attempting to se...

[The situation of dengue in the world].

The situation of dengue in the world can be summarized as follows: 2,5 billions persons at risk, 60 millions cases per year, and 30 000 deaths per year. The four dengue serotype...

A Global View on the Availability of Methods and Information in the Neuropathological Diagnostics of CNS Tumors: Results of an International Survey Among Neuropathological Units

Neutrophil DNA Contributes to the Antielastase Barrier during Acute Lung Inflammation

During acute lung inflammation, the airspaces are invaded by circulating neutrophils. These may then injure tissues through the release of elastase. Different natural specific i...