Holly Van Remmen - Researcher Profile

Publications

4 shown

Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis

Qitao Ran , Hanyu Liang , Minjun Gu +6 more

Glutathione peroxidase 4 (Gpx4) is uniquely involved in the detoxification of oxidative damage to membrane lipids. Our previous studies showed that Gpx4 is essential for mouse s...

2004 Journal of Biological Chemistry 254 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

Norman S. Wolf , Holly Van Remmen , Douglas C. Wallace +9 more

To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, o...

2005 Science 1701 citations

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Michael P. Murphy , Hülya Bayır , Vsevolod V. Belousov +22 more

2022 Nature Metabolism 1070 citations

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

Levi Yant , Qitao Ran , Lin Rao +6 more

2003 Free Radical Biology and Medicine 795 citations

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ORCID: 0000-0003-0883-0642

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