Publications
3 shownPhysicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity
We find that the degree of impairment of protein function by missense variants is predictable by comparative sequence analysis alone. The applicable range of impairment is not c...
Distribution and intensity of constraint in mammalian genomic sequence
Comparisons of orthologous genomic DNA sequences can be used to characterize regions that have been subject to purifying selection and are enriched for functional elements. We h...
Frequent Co-Authors
Researcher Info
- h-index
- 3
- Publications
- 3
- Citations
- 2,430
- Institution
- Statistical Service
External Links
Identifiers
- ORCID
- 0000-0002-2725-4209
Impact Metrics
h-index
3
h-index: Number of publications with at least h citations each.