Dan Hultmark

Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in <i>Drosophila</i>

Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipop...

A family of peptidoglycan recognition proteins in the fruit fly<i>Drosophila melanogaster</i>

Peptidoglycans from bacterial cell walls trigger immune responses in insects and mammals. A peptidoglycan recognition protein, PGRP, has been cloned from moths as well as verteb...

Relish, a Central Factor in the Control of Humoral but Not Cellular Immunity in Drosophila

A <i>Drosophila</i> IκB kinase complex required for Relish cleavage and antibacterial immunity

Here we report the identification of a Drosophila IκB kinase complex containing DmIKKβ and DmIKKγ, homologs of the human IKKβ and IKKγ proteins. We show that this complex is req...

Activation of the <i>Drosophila</i> NF‐κB factor Relish by rapid endoproteolytic cleavage

Sequence and specificity of two antibacterial proteins involved in insect immunity