Chen-Shan Chin

Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome

The complete sequence of a human genome

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addr...

Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data

Phased diploid genome assembly with single-molecule real-time sequencing

While genome assembly projects have been successful in many haploid and inbred species, the assembly of noninbred or rearranged heterozygous genomes remains a major challenge. T...

Assembling large genomes with single-molecule sequencing and locality-sensitive hashing

Long-read, single-molecule real-time (SMRT) sequencing is routinely used to finish microbial genomes, but available assembly methods have not scaled well to larger genomes. We i...

Long-read sequence assembly of the gorilla genome

Improving on the gorilla genome Access to complete, high-quality genomes of nonhuman primates will also help us understand human biology. Gordon et al. used long-read sequencing...

Long-read, whole-genome shotgun sequence data for five model organisms

Abstract Single molecule, real-time (SMRT) sequencing from Pacific Biosciences is increasingly used in many areas of biological research including de novo genome assembly, struc...