C C Harris

Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair

Chemical carcinogens are generally activated enzymatically to electrophiles that form covalently bound carcinogen-DNA adducts. Detoxifying enzymes are competing with the activat...

p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer

Chemical and physical carcinogenesis: advances and perspectives for the 1990s.

Carcinogenesis is a multistage process driven by carcinogen-induced genetic and epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal ...

p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells