Alain Israël

The IKK Complex, a Central Regulator of NF- B Activation

The IKK kinase complex is the core element of the NF-kappaB cascade. It is essentially made of two kinases (IKKalpha and IKKbeta) and a regulatory subunit, NEMO/IKKgamma. Additi...

A role for phosphorylation and degradation in the control of NF-κB activity

The Notch1 receptor is cleaved constitutively by a furin-like convertase

The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that ...

In search of γ-secretase