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Improved tools for biological sequence comparison.
We have developed three computer programs for comparisons of protein and DNA sequences. They can be used to search sequence data bases, evaluate similarity scores, and identify ...
SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling
Abstract Comparative protein modeling is increasingly gaining interest since it is of great assistance during the rational design of mutagenesis experiments. The availability of...
Database resources of the National Center for Biotechnology Information: update
In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources...
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics ...
Significance analysis of microarrays applied to the ionizing radiation response
Microarrays can measure the expression of thousands of genes to identify changes in expression between different biological states. Methods are needed to determine the significa...
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
In this paper we report exploratory analyses of high-density oligonucleotide array data from the Affymetrix GeneChip system with the objective of improving upon currently used m...
Mathematical model for studying genetic variation in terms of restriction endonucleases.
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of ...
Singular Integrals and Differentiability Properties of Functions.
Singular integrals are among the most interesting and important objects of study in analysis, one of the three main branches of mathematics. They deal with real and complex numb...