Snakes, shapes, and gradient vector flow
Snakes, or active contours, are used extensively in computer vision and image processing applications, particularly to locate object boundaries. Problems associated with initial...
Publications
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391 publications
INFOGEST static in vitro simulation of gastrointestinal food digestion
Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestin...
Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis
Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. Objective To evaluate the risk of serious adverse outcomes in patients with COVID-19 b...
Protein complex prediction with AlphaFold-Multimer
While the vast majority of well-structured single protein chains can now be predicted to high accuracy due to the recent AlphaFold [1] model, the prediction of multi-chain prote...
Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement
<b>Background:</b> Spirometry is the most common pulmonary function test. It is widely used in the assessment of lung function to provide objective information used in the diagn...
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to impr...
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
We constructed a series of recombinant genomes which directed expression of the enzyme chloramphenicol acetyltransferase (CAT) in mammalian cells. The prototype recombinant in t...
IDBA-UD: a <i>de novo</i> assembler for single-cell and metagenomic sequencing data with highly uneven depth
Abstract Motivation: Next-generation sequencing allows us to sequence reads from a microbial environment using single-cell sequencing or metagenomic sequencing technologies. How...