The NCBI BioSystems database
The NCBI BioSystems database, found at http://www.ncbi.nlm.nih.gov/biosystems/, centralizes and cross-links existing biological systems databases, increasing their utility and t...
Publications
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163 publications
CDD: conserved domains and protein three-dimensional structure
CDD, the Conserved Domain Database, is part of NCBI's Entrez query and retrieval system and is also accessible via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml. CDD provi...
Early Lactate-Guided Therapy in Intensive Care Unit Patients
In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consis...
BEAGLE: An Application Programming Interface and High-Performance Computing Library for Statistical Phylogenetics
Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest i...
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau P301L )4510 mouse expresses the P301L mutation in tau (4R0N) associated with f...
The Influence of Hospital Volume on Survival after Resection for Lung Cancer
Patients who undergo resection for lung cancer at hospitals that perform large numbers of such procedures are likely to survive longer than patients who have such surgery at hos...
Prediction of Mortality and Morbidity With a 6-Minute Walk Test in Patients With Left Ventricular Dysfunction
<h3>Objective.</h3> —To study the potential usefulness of the 6-minute walk test, a self-paced submaximal exercise test, as a prognostic indicator in patients with left ventricu...
Material challenge for flexible organic devices
Outside of the active device layers, there are a variety of requisite functional layers in flexible organic electronic devices. Whether the application is in displays, lighting,...
Simplified Therapeutic Intervention Scoring System
Objectives To validate a simplified version of the Therapeutic Intervention Scoring System, the TISS-28, and to determine the association of TISS-28 with the time spent on score...
Maternal Attachment
Abstract To determine whether present hospital practices may affect later maternal behavior, we placed 28 primiparous women in two study groups shortly after delivery of normal ...
The semiclassical theory of laser cooling
This paper reviews the basic theory of the mechanical action of light in resonant interaction with atoms. At present the main application is laser cooling, but the approach is a...