Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer. PD-L1 expression in at least 50% of tumor...
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520 publications
Toward understanding the origin and evolution of cellular organisms
Abstract In this era of high‐throughput biology, bioinformatics has become a major discipline for making sense out of large‐scale datasets. Bioinformatics is usually considered ...
KEGG for taxonomy-based analysis of pathways and genomes
Abstract KEGG (https://www.kegg.jp) is a manually curated database resource integrating various biological objects categorized into systems, genomic, chemical and health informa...
Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries
In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global pol...
Hepatocellular carcinoma
Liver cancer remains a global health challenge, with an estimated incidence of >1 million cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cance...
Pembrolizumab versus Ipilimumab in Advanced Melanoma
The anti-PD-1 antibody pembrolizumab prolonged progression-free survival and overall survival and had less high-grade toxicity than did ipilimumab in patients with advanced mela...
The State of World Fisheries and Aquaculture 2022
The designations employed and the presentation of material in this information product do not imply the expression of any opinion whatsoever on the part of the Food and Agricult...
Content Analysis: An Introduction to Its Methodology
"The Second Edition of Content Analysis is a sourcebook of the history and core principles of content analysis as well as an essential resource for present and future studies. T...
Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin
Taxonomic classification of marker-gene sequences is an important step in microbiome analysis. We present q2-feature-classifier (https://github.com/qiime2/q2-feature-classifier)...
Hepatocellular carcinoma
Hepatocellular carcinoma (HCC), one of the most frequent tumors in the world, is included by the World Health Organization as a relevant public health problem in areas of high i...
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we ...
Some Elements of a Sociology of Translation: Domestication of the Scallops and the Fishermen of St Brieuc Bay
This paper outlines a new approach to the study of power, that of the sociology of translation. Starting from three principles, those of agnosticism (impartiality between actors...