Helplessness: On Depression, Development, and Death
Overview - depression, golden girl, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability - voluntary responding, response independence and...
Publications
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413 publications
Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a plat...
World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)
An unprecedented outbreak of pneumonia of unknown aetiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus was identified as the causative ...
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding.
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the de...
UniProt: the Universal Protein Knowledgebase in 2023
Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional inf...
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and sy...
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
This review is an updated and expanded version of the five prior reviews that were published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic ag...